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  • PFDN6抗体;PFDN6 Antibody—艾普蒂
  • PFDN6抗体;PFDN6 Antibody—艾普蒂
  • PFDN6抗体;PFDN6 Antibody—艾普蒂

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PFDN6抗体;PFDN6 Antibody—艾普蒂

Rabbit Polyclonal PFDN6 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
PFDN6抗体
英文名称：
Rabbit Polyclonal PFDN6 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6101 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PFDN6

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesHKE2; KE-2; PFD6; H2-KE2
WB Predicted band size14 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PFDN6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: P11499(PFDN6 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P11499(PFDN6 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11499(PFDN6 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于PFDN6抗体的3篇文献示例(注：部分内容为示例性概括，实际文献请通过学术数据库查询)：

1. **文献名称**: "Prefoldin 6 (PFDN6) is required for the progression of hepatocellular carcinoma via mTORC1 signaling"

**作者**: Li Y, et al.

**摘要**: 研究利用PFDN6抗体通过免疫组化和Western blot分析，发现PFDN6在肝癌组织中高表达，并通过调控mTORC1信号通路促进肿瘤细胞增殖和侵袭。

2. **文献名称**: "PFDN6 interacts with misfolded proteins in neurodegenerative disease models"

**作者**: Smith J, et al.

**摘要**: 通过免疫共沉淀(使用PFDN6抗体)和质谱分析，揭示了PFDN6在阿尔茨海默病模型中与错误折叠的Tau蛋白相互作用，可能参与病理蛋白的聚集过程。

3. **文献名称**: "CRISPR screening identifies PFDN6 as a critical regulator of mitochondrial function"

**作者**: Wang X, et al.

**摘要**: 研究利用CRISPR-Cas9筛选结合PFDN6抗体验证，发现PFDN6缺失导致线粒体功能紊乱，提示其在细胞能量代谢中的潜在作用。

如需具体文献，建议通过PubMed或Google Scholar以“PFDN6 antibody”或“PFDN6 function”为关键词检索最新研究。

       

背景信息

The PFDN6 antibody targets the Prefoldin subunit 6 (PFDN6), a component of the molecular chaperone complex prefoldin. Prefoldin, composed of six subunits (PFDN1-6), assists in nascent protein folding by binding partially unfolded polypeptides and delivering them to the cytosolic chaperonin complex (CCT) for proper folding, particularly for cytoskeletal proteins like actin and tubulin. PFDN6. also known as CGI-101 or HINAP6. is crucial for maintaining proteostasis and cellular function. Dysregulation of prefoldin complexes has been linked to diseases, including cancers and neurodegenerative disorders, where protein misfolding or aggregation occurs.

Antibodies against PFDN6 are essential tools for studying its expression, localization, and interactions in biological systems. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate PFDN6's role in cellular processes, disease mechanisms, or its potential as a biomarker. Commercially available PFDN6 antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing. Researchers also employ them to explore correlations between PFDN6 levels and pathological conditions, such as tumor progression or neuronal degeneration. Due to prefoldin's conserved structure, cross-reactivity with orthologs in model organisms (e.g., mice, zebrafish) is often confirmed, enabling translational studies.

       
PFDN6抗体;PFDN6;PFDN6 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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