ASB9抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: P09207(ASB9 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09207(ASB9 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The Ankyrin repeat and SOCS box protein 9 (ASB9) is a member of the ASB family, characterized by an N-terminal ankyrin repeat domain and a C-terminal SOCS box motif. It functions as a substrate-recognition component within E3 ubiquitin ligase complexes, targeting specific proteins for ubiquitination and subsequent proteasomal degradation. ASB9 is notably involved in regulating cellular processes such as cell cycle progression, signal transduction, and energy metabolism. Studies have shown that ASB9 interacts with mitochondrial creatine kinase (MtCK), modulating its stability and activity, which links ASB9 to ATP regeneration and cellular energy homeostasis. Dysregulation of ASB9 has been implicated in cancer, with altered expression observed in renal cell carcinoma, glioblastoma, and other malignancies, suggesting its potential role in tumorigenesis or tumor suppression depending on context.

ASB9 antibodies are essential tools for investigating its expression, localization, and molecular interactions. They enable detection of endogenous ASB9 via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also use these antibodies for co-immunoprecipitation to identify binding partners, such as MtCK or components of the ubiquitination machinery. Commercial ASB9 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat samples. Their applications extend to studying ASB9's involvement in diseases, including cancer metabolism and neurological disorders, providing insights into therapeutic targeting of ubiquitin-proteasome pathways. Ongoing research aims to clarify ASB9's dual roles in cellular regulation and pathology, emphasizing its context-dependent functions.