基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 ZNF473抗体 ZNF473抗体
  • ZNF473抗体—艾普蒂
  • ZNF473抗体—艾普蒂
  • ZNF473抗体—艾普蒂

1/3

ZNF473抗体—艾普蒂

Rabbit Polyclonal ZNF473 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
ZNF473抗体
英文名称：
Rabbit Polyclonal ZNF473 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4663 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ZNF473

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesZN473; ZFP100
WB Predicted band size100 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ZNF473
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell lysate, Primary antibody: P09218(ZNF473 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09218(ZNF473 Antibody) at dilution 1/80. (Original magnification: ×200)    


           

参考文献

以下是3篇与ZNF473抗体相关的文献示例(注：文献信息为模拟概括，实际引用请以真实文献为准)：

---

1. **文献名称**: *ZNF473 interacts with spliceosomal proteins and promotes RNA processing in human cells*

**作者**: Miyake, K. et al.

**摘要**: 研究报道ZNF473蛋白通过与剪接体核心组分(如PRPF8)相互作用，调控pre-mRNA剪接过程。文章使用ZNF473抗体进行免疫共沉淀实验，验证其在RNA加工中的功能，并发现其缺失导致剪接异常。

---

2. **文献名称**: *Zinc finger protein 473 is a novel regulator of pluripotency in embryonic stem cells*

**作者**: Lee, S. & Zhu, H.

**摘要**: 本研究通过ZNF473抗体染色和ChIP-seq分析，发现ZNF473直接结合OCT4启动子区，维持胚胎干细胞多能性。敲低ZNF473导致多能性基因表达下调，提示其在干细胞自我更新中的关键作用。

---

3. **文献名称**: *Antibody-based profiling of ZNF473 reveals overexpression in breast cancer and correlation with poor prognosis*

**作者**: Smith, J.R. & Johnson, A.L.

**摘要**: 利用ZNF473抗体对乳腺癌组织进行免疫组化分析，发现ZNF473在肿瘤组织中显著高表达，且与患者生存率负相关。机制研究表明其通过调控DNA修复通路促进肿瘤进展。

---

4. **文献名称**: *Characterization of ZNF473 knockout mice using specific antibody validation*

**作者**: Nagase, T. et al.

**摘要**: 研究通过ZNF473抗体验证基因敲除小鼠模型，发现ZNF473缺失导致发育缺陷和基因组不稳定性，提示其在DNA损伤应答中的潜在功能。

---

(注：以上为模拟文献，实际研究中请通过PubMed或Google Scholar以“ZNF473 antibody”为关键词检索真实文献。)

       

背景信息

**Background of ZNF473 Antibody**

ZNF473 (Zinc Finger Protein 473) is a member of the zinc finger protein family, characterized by conserved C2H2-type zinc finger motifs that mediate DNA or RNA binding. This protein is implicated in transcriptional regulation, chromatin remodeling, and DNA repair processes. Studies suggest ZNF473 interacts with the spliceosome complex, potentially influencing pre-mRNA splicing, and associates with proteins involved in maintaining genomic stability, such as those in the Fanconi anemia pathway.

Antibodies targeting ZNF473 serve as critical tools for investigating its expression, localization, and molecular functions. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous ZNF473 in various cell types or tissues. Validated antibodies typically exhibit specificity for ZNF473 through knockout cell line controls, ensuring minimal cross-reactivity with related zinc finger proteins.

Research utilizing ZNF473 antibodies has highlighted its role in cellular stress responses and cancer biology. For instance, altered ZNF473 expression has been observed in malignancies, suggesting potential involvement in tumorigenesis or therapy resistance. Additionally, its interaction with DNA damage response pathways underscores its importance in maintaining genomic integrity. Commercial ZNF473 antibodies are often raised in rabbits or mice, with epitopes mapped to conserved regions of the protein. Proper validation remains essential for reliable experimental outcomes, particularly in studies exploring ZNF473's mechanistic contributions to disease.

       
ZNF473抗体;ZNF473;ZNF473 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

ZNF473抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价