ZPR1抗体—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela, HEPG2, 231, A431 and Jurkat cell lysates, Primary antibody: P09232(ZPR1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09232(ZPR1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09232(ZPR1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

ZPR1 antibody is a research tool used to detect and study the zinc finger protein ZPR1. which plays critical roles in cellular processes such as cell cycle regulation, DNA damage response, and mitochondrial function. ZPR1. encoded by the *ZPR1* gene in humans, is a conserved eukaryotic protein that interacts with survival motor neuron (SMN) complexes and SURF1. a protein involved in mitochondrial cytochrome c oxidase assembly. It is implicated in maintaining genomic stability and cellular stress responses, with its dysfunction linked to neurodegenerative disorders, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).

The ZPR1 antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ZPR1 expression, localization, and protein-protein interactions. Studies using this antibody have revealed ZPR1's nuclear-cytoplasmic shuttling behavior and its role in neuronal survival. Researchers also employ ZPR1 antibodies to explore its potential as a biomarker or therapeutic target in diseases associated with mitochondrial dysfunction or motor neuron degeneration.

Commercial ZPR1 antibodies are typically raised in rabbits or mice, with validation including knockout controls to ensure specificity. Ongoing research focuses on clarifying ZPR1's molecular mechanisms, particularly its interplay with SMN complexes in SMA pathogenesis and its contribution to oxidative stress responses in neurodegeneration.