ZNF302抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 30 μg, Lane: 231 cells, Primary antibody: P00080(MMP7 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The ZNF302 antibody is a tool used to study the zinc finger protein 302 (ZNF302), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF302 functions as a transcriptional repressor by binding to specific DNA sequences through its C2H2-type zinc finger motifs, which mediate sequence recognition, and its KRAB domain, which recruits co-repressors like KAP1 to establish heterochromatin and silence target genes. This protein is implicated in regulating cellular processes such as differentiation, proliferation, and apoptosis. Studies suggest its involvement in embryonic development and tissue homeostasis, though its exact biological roles remain under investigation.

Antibodies against ZNF302 are primarily utilized in research to detect and quantify the protein in various experimental models, including immunohistochemistry (IHC), Western blotting, and immunofluorescence. These antibodies help elucidate ZNF302's expression patterns, subcellular localization (typically nuclear), and interactions with chromatin or other regulatory complexes. Notably, ZNF302 has been linked to cancer biology, where it may act as either an oncogene or tumor suppressor depending on cellular context, modulating pathways like Wnt/β-catenin or p53. Dysregulation of ZNF302 has been observed in malignancies such as hepatocellular carcinoma and gliomas. The antibody thus serves as a critical reagent for exploring ZNF302's role in epigenetic regulation, disease mechanisms, and potential therapeutic targeting. Commercial ZNF302 antibodies are typically validated for specificity using knockout/knockdown controls.