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  • BUD31抗体—艾普蒂
  • BUD31抗体—艾普蒂
  • BUD31抗体—艾普蒂

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BUD31抗体—艾普蒂

Rabbit Polyclonal BUD31 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
BUD31抗体
英文名称：
Rabbit Polyclonal BUD31 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4789 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
BUD31

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesG10; EDG2; Cwc14; EDG-2; fSAP17; YCR063W
WB Predicted band size17 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human testis tissue, Mouse brain tissue, Mouse heart tissue, PC-3 cell, 231 cell, Raji and Jurkat cell lysates, Primary antibody: P09381(BUD31 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09381(BUD31 Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09381(BUD31 Antibody) at dilution 1/75. (Original magnification: ×200)    


           

参考文献

以下是关于BUD31抗体的参考文献示例(文献内容为模拟概括，建议通过数据库核实原文)：

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1. **Title**: "BUD31 links the spliceosome to the DNA damage response in human cells"

**Author**: Smith A, et al.

**Summary**: 本研究利用BUD31抗体通过免疫沉淀和蛋白质组学分析，揭示了BUD31作为剪接体组分在DNA损伤修复中的新功能，证明其缺失导致基因组不稳定性增加。

2. **Title**: "G10 (BUD31) as a novel prognostic marker in colorectal cancer"

**Author**: Chen L, et al.

**Summary**: 通过BUD31抗体的免疫组化分析，发现BUD31在结直肠癌组织中高表达，且与患者生存率负相关，提示其可能作为潜在治疗靶点。

3. **Title**: "Role of BUD31 in cell cycle regulation via pre-mRNA splicing"

**Author**: Kim J, et al.

**Summary**: 使用BUD31抗体进行Western blot和RNA干扰实验，证实BUD31通过调控特定细胞周期相关基因的剪接，影响G1/S期转换。

4. **Title**: "BUD31-mediated splicing defects contribute to neurodegenerative disease pathology"

**Author**: Garcia R, et al.

**Summary**: 通过BUD31抗体的免疫荧光染色，发现阿尔茨海默病模型中BUD31表达异常，导致tau蛋白剪接异常，加剧神经元功能障碍。

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建议通过PubMed或Google Scholar以“BUD31 antibody”为关键词检索最新文献，并关注涉及该抗体在蛋白质互作、疾病机制或诊断应用中的研究。

       

背景信息

The BUD31 antibody is a valuable tool for studying the molecular role of the BUD31 protein, a conserved eukaryotic factor implicated in pre-mRNA splicing and cell cycle regulation. Originally identified in *Saccharomyces cerevisiae* for its role in bud-site selection, BUD31 is now recognized as a core component of the spliceosome, the macromolecular complex responsible for removing introns from precursor mRNA. In humans, BUD31 (also called CCDC51 or LUC7L3) interacts with spliceosomal proteins like SF3B1 and PRPF19. contributing to spliceosome assembly and catalytic activation. Its involvement in mRNA processing links it to diverse cellular processes, including transcription, DNA repair, and apoptosis. Dysregulation of BUD31 has been associated with cancers, neurological disorders, and developmental defects, highlighting its biological significance.

BUD31 antibodies are commonly raised against specific epitopes of the human or murine BUD31 protein and are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and protein interactions. These antibodies aid in exploring BUD31's role in splicing fidelity, its potential as a biomarker in diseases, and its response to splicing-modulating therapies. Validation for specificity and cross-reactivity is critical due to structural similarities among spliceosomal components. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary depending on application needs.

       
BUD31抗体;BUD31;BUD31 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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