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  • COA7抗体—艾普蒂
  • COA7抗体—艾普蒂
  • COA7抗体—艾普蒂

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COA7抗体—艾普蒂

Rabbit Polyclonal COA7 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
COA7抗体
英文名称：
Rabbit Polyclonal COA7 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4811 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
COA7

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRESA1; SELRC1; C1orf163
WB Predicted band size26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HL-60 and HEPG2 cell lysates, Primary antibody: P09404(COA7 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09404(COA7 Antibody) at dilution 1/55. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09404(COA7 Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是关于COA7抗体的3篇参考文献示例(注：以下信息为基于领域知识的模拟内容，具体文献需通过学术数据库核实)：

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1. **文献名称**: *COA7 is essential for mitochondrial complex IV assembly and interacts with COX18 to stabilize the MITRAC complex*

**作者**: Müller JS, et al.

**摘要**: 本研究通过COA7特异性抗体进行免疫沉淀和Western blot分析，揭示了COA7在维持线粒体复合物IV(COX)组装中的关键作用，并发现其与COX18蛋白相互作用以稳定MITRAC复合物，从而影响线粒体呼吸功能。

2. **文献名称**: *A novel homozygous mutation in COA7 causes fatal infantile mitochondrial encephalopathy*

**作者**: Park S, et al.

**摘要**: 报道一例由COA7基因纯合突变导致的线粒体脑病病例，使用COA7抗体检测患者成纤维细胞中蛋白表达显著降低，证实突变导致COA7功能丧失，引发线粒体呼吸链缺陷和神经元退行性变。

3. **文献名称**: *Generation and validation of a polyclonal antibody targeting human COA7 for functional studies*

**作者**: Chen L, et al.

**摘要**: 描述了一种新型兔源多克隆抗体的开发，通过免疫印迹和免疫荧光验证其对人类COA7蛋白的特异性，并应用于细胞模型中研究COA7的亚线粒体定位及动态表达变化。

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**提示**：实际文献需通过PubMed、Google Scholar等平台以关键词“COA7 antibody”或“COA7 mitochondrial function”检索。建议结合研究背景筛选涉及抗体应用(如Western blot、免疫组化)的论文。

       

背景信息

The COA7 (Cytochrome c Oxidase Assembly Factor 7) antibody is a research tool used to study the COA7 protein, which plays a critical role in mitochondrial function. COA7. also known as SELENOT or RESF1. is a mitochondrial matrix protein involved in the assembly and stability of Complex IV (cytochrome c oxidase) of the electron transport chain. It facilitates the incorporation of heme and copper cofactors into the enzyme, ensuring proper oxidative phosphorylation. Mutations in the COA7 gene are linked to mitochondrial disorders, such as Leigh syndrome and Charcot-Marie-Tooth disease, characterized by neurodegeneration and muscle weakness.

The COA7 antibody is typically utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect COA7 expression levels, subcellular localization, and tissue distribution. Studies employing this antibody have revealed reduced COA7 levels in disease models, highlighting its role in mitochondrial dysfunction and cellular stress responses. Researchers also investigate its interaction with other mitochondrial proteins to unravel molecular mechanisms underlying energy metabolism defects. Commercial COA7 antibodies are often raised in rabbits or mice, validated for specificity using knockout controls. Its application advances understanding of mitochondrial biology and potential therapeutic targets for metabolic and neurological diseases.

       
COA7抗体;COA7;COA7 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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