MRPL16抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HT-29 and 293T cell lysates, Primary antibody: P10072(MRPL16 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10072(MRPL16 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The MRPL16 antibody is a research tool designed to detect and study the mitochondrial ribosomal protein L16 (MRPL16), a component of the mitochondrial ribosome large subunit (39S). Mitochondria possess their own translation machinery to synthesize essential subunits of the electron transport chain (ETC) complexes, which are critical for oxidative phosphorylation and cellular energy production. MRPL16 plays a structural and functional role in maintaining the integrity of the mitochondrial ribosome, facilitating the assembly and stability required for mitochondrial protein synthesis.

Antibodies targeting MRPL16 are utilized in various applications, including Western blotting, immunofluorescence, and immunoprecipitation, to investigate its expression, localization, and interactions. Research involving MRPL16 is particularly relevant in studies of mitochondrial dysfunction, as impaired mitochondrial translation is linked to metabolic disorders, neurodegenerative diseases, and cancer. Dysregulation of MRPL16 has been observed in certain cancers, suggesting its potential role in tumorigenesis or metabolic reprogramming.

These antibodies also aid in exploring the molecular basis of mitochondrial ribosomopathies and genetic mutations affecting mitochondrial gene expression. Validated MRPL16 antibodies are essential for distinguishing between cytosolic and mitochondrial translation processes, enabling precise analysis of mitochondrial proteostasis. Species specificity (e.g., human, mouse) and cross-reactivity should be confirmed for experimental accuracy. Overall, MRPL16 antibodies serve as critical tools for advancing our understanding of mitochondrial biology and associated pathologies.