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  • GEMIN7抗体—艾普蒂
  • GEMIN7抗体—艾普蒂
  • GEMIN7抗体—艾普蒂

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GEMIN7抗体—艾普蒂

Rabbit Polyclonal GEMIN7 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-21

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
GEMIN7抗体
英文名称：
Rabbit Polyclonal GEMIN7 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5384 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
GEMIN7

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSIP3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human GEMIN7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10241(GEMIN7 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于GEMIN7抗体的3篇参考文献示例(注：部分内容为示例性概括，具体文献需根据实际检索结果调整)：

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1. **文献名称**: "GEMIN7 is a critical component of the survival motor neuron complex required for snRNP assembly"

**作者**: Carissimi C., et al.

**摘要**: 本研究揭示了GEMIN7在SMN复合物中的关键作用，通过特异性抗体验证其与GEMIN2、GEMIN4的相互作用，证明其对于小核核糖核蛋白(snRNP)的组装至关重要，并参与脊髓性肌萎缩症(SMA)的病理机制。

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2. **文献名称**: "The SMN complex mediates snRNP assembly in vivo via distinct subcomplexes"

**作者**: Feng W., et al.

**摘要**: 作者利用GEMIN7抗体进行免疫共沉淀和免疫荧光实验，发现SMN复合物在体内通过动态亚复合物形式存在，GEMIN7的稳定性依赖于GEMIN6.为SMA相关蛋白互作网络提供了新见解。

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3. **文献名称**: "GEMIN7 promotes efficient nuclear RNAi by preventing RISC activation in the cytoplasm"

**作者**: Ma Z., et al.

**摘要**: 通过Western blot和免疫定位实验(使用GEMIN7抗体)，研究发现GEMIN7不仅参与snRNP生成，还在RNA干扰(RNAi)通路中调控RISC复合体的细胞质活化，拓展了其功能多样性。

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**备注**：以上文献为示例，实际引用时建议通过PubMed或Web of Science以“GEMIN7 antibody”为关键词检索最新研究，并关注其抗体应用场景(如WB、IP、IF等)及功能研究。

       

背景信息

The GEMIN7 antibody is a crucial tool for studying the GEMIN7 protein, a component of the Survival of Motor Neuron (SMN) complex. The SMN complex plays a vital role in small nuclear ribonucleoprotein (snRNP) assembly, essential for pre-mRNA splicing and mRNA processing in eukaryotic cells. GEMIN7. along with other GEMIN proteins (GEMIN2-8), stabilizes the SMN complex by forming heterodimers with GEMIN6. contributing to its structural integrity and function. Dysregulation of SMN complex components, including GEMIN7. is linked to spinal muscular atrophy (SMA), a genetic disorder caused by mutations in the SMN1 gene, leading to motor neuron degeneration.

GEMIN7 antibodies are widely used in research to investigate SMN complex dynamics, spliceosome assembly, and their roles in neurodegenerative diseases. These antibodies enable detection and localization of GEMIN7 in various experimental setups, such as Western blotting, immunofluorescence, and immunoprecipitation. They are particularly valuable in studying SMA pathogenesis, as reduced SMN protein levels impair snRNP assembly, disrupting splicing mechanisms. Additionally, GEMIN7 antibodies aid in exploring broader biological contexts, including developmental processes and cellular stress responses. Their specificity and reliability make them indispensable for elucidating molecular mechanisms underlying RNA metabolism and neuromuscular disorders.

       
GEMIN7抗体;GEMIN7;GEMIN7 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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