TOE1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell lysate, Primary antibody: P10556(TOE1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10556(TOE1 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

The TOE1 (Target of EGR1) antibody is a tool used to study the TOE1 protein, a ubiquitin-specific protease involved in RNA metabolism and cellular homeostasis. TOE1 is part of the Uba4 family, characterized by its role in processing and degrading RNAs, particularly non-coding RNAs and aberrant transcripts. It localizes to the nucleus and Cajal bodies, where it interacts with components of the RNA exosome and telomerase complexes, influencing RNA quality control and telomere maintenance.

Mutations in the TOE1 gene are linked to human diseases, including pontocerebellar hypoplasia type 7 (PCH7), a severe neurodevelopmental disorder characterized by cerebellar atrophy, microcephaly, and respiratory failure. This association underscores TOE1's critical role in neuronal development and survival.

TOE1 antibodies are widely used in research to investigate its expression, localization, and molecular interactions. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping elucidate TOE1's regulatory mechanisms in RNA processing, stress responses, and disease pathways. Recent studies also explore its potential involvement in cancer, such as modulating tumor suppressor or oncogenic signals. As a reagent, TOE1 antibodies are vital for advancing understanding of RNA biology and neurodegenerative or cancerous conditions linked to TOE1 dysfunction.