PTBP2抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: HepG2 cell, LOVO cell, Hela cell, Mouse testis tissue lysates, Primary antibody: P10559(PTBP2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10559(PTBP2 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10559(PTBP2 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

PTBP2 (Polypyrimidine Tract-Binding Protein 2), also known as nPTB or brPTB, is an RNA-binding protein belonging to the PTB/hnRNP I family. It shares structural homology with PTBP1 but exhibits distinct expression patterns and regulatory roles. Primarily expressed in the brain, muscle, and testis, PTBP2 is crucial for neural development, where it regulates alternative splicing, mRNA transport, and stability of transcripts involved in neuronal differentiation and synaptic plasticity. Unlike PTBP1. which is abundant in non-neuronal cells, PTBP2 becomes upregulated during neuronal maturation, suppressing PTBP1 to promote cell-specific splicing events essential for neurogenesis.

PTBP2 antibodies are vital tools for studying its expression dynamics, interactions, and functional mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping researchers map its tissue distribution and subcellular localization. Studies using PTBP2 antibodies have revealed its involvement in neurological disorders, such as Alzheimer’s disease and brain tumors, where dysregulated splicing contributes to pathogenesis. Additionally, PTBP2 has been implicated in cancer progression, with aberrant expression linked to metastasis and therapy resistance in certain malignancies.

The development of specific PTBP2 antibodies has advanced research into RNA metabolism and post-transcriptional regulation, offering insights into cell-specific gene expression programs. Their application continues to support investigations into developmental biology, disease mechanisms, and potential therapeutic targets.