DDX46抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10607(DDX46 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10607(DDX46 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The DDX46 antibody is a research tool designed to detect and study the DEAD-box helicase 46 (DDX46) protein, a member of the DEAD-box RNA helicase family. These proteins are characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif and play critical roles in RNA metabolism, including unwinding RNA secondary structures, regulating RNA splicing, and facilitating ribosome biogenesis. DDX46 is implicated in diverse cellular processes, such as pre-mRNA processing, nuclear export of RNA, and antiviral immune responses. It localizes primarily to the nucleus, particularly within nucleoli and nuclear speckles, reflecting its involvement in ribosomal RNA maturation and spliceosome assembly.

Antibodies targeting DDX46 are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, subcellular distribution, and interactions with other biomolecules. Studies have linked DDX46 to pathological conditions, including cancer and viral infections. For example, elevated DDX46 expression has been observed in certain malignancies, suggesting a potential role in tumor progression. Additionally, DDX46 interacts with viral RNAs or proteins, modulating host antiviral signaling pathways, such as the RIG-I-like receptor pathway.

Researchers validate DDX46 antibodies using knockout cell lines or siRNA-mediated knockdown to ensure specificity. These reagents are essential for elucidating DDX46's molecular mechanisms and therapeutic potential in diseases involving RNA dysregulation.