FOXJ3抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: P10864(FOXJ3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The FOXJ3 antibody is a tool used to detect and study the FOXJ3 protein, a member of the Forkhead box (FOX) family of transcription factors. FOX proteins are characterized by a conserved DNA-binding domain termed the "forkhead box," which regulates gene expression by interacting with specific DNA sequences. FOXJ3. part of the FOXJ subfamily, is less extensively studied compared to other FOX members like FOXO or FOXP. It is implicated in diverse biological processes, including cilia formation, spermatogenesis, and tissue development. Studies suggest FOXJ3 may play roles in cell differentiation, motility, and possibly cancer progression, though its precise mechanisms remain unclear.

FOXJ3 antibodies are typically monoclonal or polyclonal, generated using immunogenic peptides from conserved regions of the protein. They enable applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to localize FOXJ3 in tissues or cells. Researchers use these antibodies to explore FOXJ3's expression patterns, interactions, and regulatory functions in developmental and disease contexts. Commercial FOXJ3 antibodies are often validated for specificity via knockout controls or siRNA knockdown.

Despite its emerging relevance, FOXJ3 research is limited, and available antibodies vary in quality across suppliers. Ongoing studies aim to clarify its role in cellular homeostasis, fertility, and pathologies like ciliopathies or cancers, highlighting the need for reliable detection tools.