BABAM1抗体—艾普蒂 新品

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     IHC-P analysis of testis tissue by BABAM1 antibody (P15869) IHC-P was performed using sections of the formalin-fixed paraffin-embedded testis tissue;Result: Cells in seminiferous ducts are positively stained at the nuclei and cytoplasm.    

  
  

**Background of BABAM1 Antibody**

BABAM1 (BRISC and BRCA1-A complex member 1), also known as CCDC98 or BRE, is a multifunctional protein implicated in DNA damage response, cell cycle regulation, and immune signaling. It serves as a critical component of two distinct complexes: the BRCA1-A complex, which facilitates DNA repair through homologous recombination by deubiquitinating γ-H2AX, and the BRISC complex, which regulates inflammatory signaling by modulating type I interferon and NF-κB pathways.

BABAM1 antibodies are valuable tools for studying its role in maintaining genomic stability and its association with diseases. Research highlights BABAM1's interaction with BRCA1. linking it to breast and ovarian cancers, particularly in individuals with BRCA1 mutations. Additionally, BRISC-associated BABAM1 has been implicated in autoimmune disorders and chronic inflammation, emphasizing its dual context-dependent functions.

Antibodies targeting BABAM1 are used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to analyze expression levels, subcellular localization, and protein-protein interactions. Studies utilizing these antibodies have revealed BABAM1's modular structure, including tandem BRCA1-binding domains and coiled-coil regions essential for complex assembly.

Overall, BABAM1 antibodies advance understanding of its contributions to cancer biology, immune regulation, and potential therapeutic targeting, making them crucial for both basic research and clinical applications.