MCF2L2抗体—艾普蒂 新品

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     IHC-P analysis of brain tissue by MCF2L2 antibody (P15950) IHC-P was performed using sections of the formalin-fixed paraffin-embedded brain tissue;Result: Neuronal cells and glial cells are positively stained at the nuclei.    

  
  

The MCF2L2 antibody targets the MCF2-like protein 2 (MCF2L2), a guanine nucleotide exchange factor (GEF) encoded by the *MCF2L2* gene. MCF2L2 regulates Rho GTPases, particularly Rac1 and Cdc42. which are critical for cytoskeletal dynamics, cell motility, and intracellular signaling. This protein contains a Dbl homology (DH) domain responsible for GEF activity and a pleckstrin homology (PH) domain involved in membrane targeting. MCF2L2 is implicated in neuronal development, cancer progression, and other cellular processes linked to Rho GTPase signaling dysregulation.

Antibodies against MCF2L2 are essential tools for studying its expression, localization, and function in vitro and in vivo. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate MCF2L2's role in diseases such as cancer, where aberrant Rho signaling may drive metastasis, or neurodevelopmental disorders. Commercial MCF2L2 antibodies are typically raised in hosts like rabbits or mice, with validation across specific applications. Researchers rely on these antibodies to explore MCF2L2's interactions with signaling pathways, its regulatory mechanisms, and potential therapeutic targeting. However, batch variability and specificity challenges necessitate careful validation using knockout controls or siRNA-based approaches to ensure accurate experimental outcomes.