MEF2D抗体;MEF2D Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12783(MEF2D Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12783(MEF2D Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The MEF2D antibody is a crucial tool for studying the myocyte enhancer factor 2D (MEF2D) protein, a member of the MEF2 transcription factor family. MEF2D, encoded by the *MEF2D* gene, regulates gene expression by binding to specific DNA sequences via its conserved MADS-box and MEF2 domains. It plays pivotal roles in cellular processes such as muscle development, neuronal differentiation, and apoptosis. MEF2D is also implicated in oncogenesis, particularly in hematologic malignancies (e.g., acute leukemia with *RBM15-MEF2D* fusion) and solid tumors. Dysregulation of MEF2D has been linked to neurodegenerative disorders, including Alzheimer’s disease, where its activity influences synaptic plasticity and neuronal survival.

MEF2D antibodies are widely used in techniques like Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence to detect protein expression, localization, and DNA-binding interactions. These antibodies help elucidate MEF2D’s regulatory mechanisms, such as its post-translational modifications (e.g., phosphorylation, acetylation) and interactions with cofactors like histone deacetylases (HDACs). Commercially available MEF2D antibodies vary in host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and epitope specificity. Validation across species (human, mouse, rat) and applications ensures reliability in diverse experimental models. Researchers prioritize antibodies with high specificity and low cross-reactivity to avoid off-target effects, especially given MEF2D’s structural homology with other MEF2 family members (MEF2A/B/C). This antibody remains indispensable for dissecting MEF2D’s role in development, disease, and potential therapeutic targeting.