UBXN10抗体;UBXN10 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12910(UBXN10 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The UBXN10 antibody is a tool used to detect the UBXN10 protein, a member of the UBX domain-containing protein family. UBXN10. also known as UBXD10 or FAS-associated factor 2 (FAF2), plays roles in cellular processes such as endoplasmic reticulum-associated degradation (ERAD), lipid droplet regulation, and apoptosis. It interacts with key proteins like p97/VCP (valosin-containing protein), linking it to ubiquitin-proteasome pathways and protein quality control. UBXN10’s involvement in ERAD highlights its importance in clearing misfolded proteins, while its lipid droplet association suggests regulatory functions in lipid metabolism.

Antibodies targeting UBXN10 are typically developed in hosts like rabbits or mice, using immunogens derived from specific regions of the human UBXN10 sequence. These antibodies are validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation, aiding in studies of UBXN10’s expression, localization, and interactions. Researchers employ UBXN10 antibodies to explore its roles in diseases, including cancers (e.g., breast, liver) and metabolic disorders, where dysregulation of protein degradation or lipid homeostasis is implicated. Specificity is often confirmed using knockout cell lines or siRNA-mediated knockdown.

UBXN10 antibodies have become critical in elucidating the protein’s molecular mechanisms, particularly its dual roles in stress response and cellular homeostasis. Ongoing research focuses on its potential as a therapeutic target or biomarker in pathologies linked to proteostasis imbalance.