GASK1A抗体;GASK1A Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13154(GASK1A Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P13154(GASK1A Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The GASK1A (Gastric Adenocarcinoma Associated Antigen KA1A) antibody targets a protein encoded by the GASK1A gene, which belongs to the GASK (Gastric Adenocarcinoma Associated Antigen) family. GASK1A is a transmembrane protein with conserved structural domains, potentially involved in cell signaling, adhesion, or proliferation. It has garnered attention due to its overexpression in certain cancers, particularly gastric adenocarcinoma, where it may contribute to tumor progression, metastasis, or therapy resistance. Studies suggest GASK1A interacts with signaling pathways like PI3K/AKT or MAPK, though its precise biological role remains under investigation.

GASK1A antibodies are primarily used as research tools to detect protein expression and localization in tissues or cell lines via techniques like immunohistochemistry (IHC), Western blot, or immunofluorescence. Their development has facilitated exploratory studies linking GASK1A to cancer diagnostics or prognostics. For example, elevated GASK1A levels in patient serum or tumor tissues have been correlated with advanced disease stages or poor survival outcomes. Additionally, these antibodies are being evaluated for therapeutic potential, such as in antibody-drug conjugates (ADCs) or as biomarkers for targeted therapies. Commercial GASK1A antibodies are typically validated for specificity using knockout cell lines or siRNA silencing. Ongoing research aims to clarify its pathophysiological mechanisms and clinical utility across malignancies.