LTO1抗体;LTO1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13182(LTO1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P13182(LTO1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The LTO1 antibody is designed to target the LTO1 (Long Transient Oscillation 1) protein, a conserved eukaryotic protein implicated in ribosome biogenesis and RNA processing. LTO1 functions as a component of the ribosomal quality control complex, working alongside partners like PYM1 and ABCE1 to facilitate late-stage maturation of the 40S ribosomal subunit. It plays a critical role in ensuring proper cytoplasmic localization of pre-40S subunits and participates in resolving faulty ribosome assembly intermediates. Dysregulation of LTO1 has been linked to cellular stress responses and pathologies, including cancer. Studies suggest its interaction with p53 pathways may influence cell cycle arrest or apoptosis under genotoxic stress.

The LTO1 antibody is widely utilized in molecular biology research to investigate ribosome assembly mechanisms, RNA metabolism, and cancer biology. It enables detection of endogenous LTO1 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Recent applications include exploring LTO1's role in tumor progression, particularly in colorectal and lung cancers, where altered expression correlates with patient prognosis. Validated in human and murine models, this antibody serves as a key tool for elucidating LTO1's molecular functions and its potential as a therapeutic target. Commercial variants are available from suppliers like Santa Cruz Biotechnology and Abcam, often tested for specificity in knockout controls.