PCDHGB5抗体;PCDHGB5 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13185(PCDHGB5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13185(PCDHGB5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The PCDHGB5 antibody is a research tool targeting Protocadherin Gamma Subfamily B5 (PCDHGB5), a member of the protocadherin (PCDH) family. Protocadherins are transmembrane proteins involved in cell-cell adhesion and neural circuit formation, playing critical roles in neuronal development, synaptic plasticity, and tissue patterning. The gamma protocadherin cluster, located on human chromosome 5. contains 22 genes divided into A, B, and C subfamilies. PCDHGB5. part of the gamma-B subfamily, is hypothesized to contribute to neuronal diversity and connectivity through its homophilic binding properties, which mediate selective intercellular recognition.

Antibodies against PCDHGB5 are primarily used to study its expression, localization, and function in biological systems. They enable detection via techniques like immunohistochemistry, Western blotting, and immunofluorescence, aiding investigations into its role in neural development, cancer (where dysregulation is observed), and neuropsychiatric disorders. Research suggests PCDHGB5 may influence synaptic stability and axon guidance, with potential implications in neurodegenerative diseases. However, its precise mechanisms remain under exploration. Commercial PCDHGB5 antibodies are typically validated in specific applications, though cross-reactivity with related PCDH isoforms remains a consideration. Studies utilizing these antibodies contribute to unraveling the complex roles of clustered protocadherins in cellular identity and tissue organization.