REM1抗体;REM1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13188(REM1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The REM1 antibody targets the REM1 protein (Rad and Gem/Kir), a member of the RGK family of small GTP-binding proteins. REM1 regulates calcium channel activity, cytoskeletal dynamics, and cellular processes like proliferation, differentiation, and vesicle trafficking. It interacts with voltage-gated calcium channels (e.g., Cav1.2) and modulates their function, impacting cardiovascular and neuronal signaling. REM1 is also implicated in pathological conditions, including cancer, cardiovascular diseases, and neurological disorders, where its dysregulation affects cell migration, angiogenesis, and synaptic plasticity.

The REM1 antibody is widely used in research to study protein expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It helps identify REM1 in tissues and cell lines, aiding investigations into its role in disease mechanisms or signaling pathways. Commercial REM1 antibodies are typically validated for specificity in human, mouse, or rat samples. Researchers utilize these tools to explore REM1's interplay with cytoskeletal proteins, calcium signaling components, or downstream effectors, offering insights into therapeutic targets for REM1-associated disorders.