CCP110抗体;CCP110 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13213(CCP110 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13213(CCP110 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

CCP110 (Centriolar Coiled-Coil Protein 110), also known as Cep110. is a centrosomal protein critical for centriole duplication, ciliogenesis, and maintaining centrosome integrity. It localizes to the distal ends of parent centrioles and plays a role in regulating centriole length and preventing aberrant microtubule nucleation. CCP110 interacts with other centrosomal proteins, such as Cep97 and KIF24. to coordinate centrosome maturation and separation during the cell cycle.

Antibodies targeting CCP110 are widely used in research to study centrosome biology, cell cycle regulation, and cilia-related disorders. They enable the visualization of CCP110's subcellular localization via immunofluorescence and quantify its expression levels through Western blotting. Dysregulation of CCP110 has been linked to genomic instability, mitotic defects, and diseases such as cancer (e.g., breast, lung) and ciliopathies (e.g., Joubert syndrome). Studies using CCP110 antibodies have revealed its role in tumor progression, where overexpression correlates with poor prognosis, and its involvement in ciliary resorption during cell division.

These antibodies are essential tools for exploring CCP110's functional mechanisms, its interplay with signaling pathways (e.g., Hippo, PI3K/AKT), and its potential as a therapeutic target. Their specificity and reliability make them valuable in both basic research and clinical investigations of centrosome-associated pathologies.