CREG1抗体;CREG1 Antibody—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cell lysate, Primary antibody: P13216(CREG1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a secreted glycoprotein involved in regulating cellular differentiation, proliferation, and apoptosis. It interacts with the mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and modulates lysosomal function and extracellular matrix remodeling. Dysregulation of CREG1 has been linked to cancer, cardiovascular diseases, and metabolic disorders, highlighting its role in maintaining cellular homeostasis.

CREG1 antibodies are immunological tools developed to detect and quantify CREG1 protein expression in research and diagnostic applications. These antibodies are typically generated using recombinant CREG1 protein or specific peptide epitopes, enabling their use in techniques like Western blotting, immunohistochemistry (IHC), and ELISA. They help investigate CREG1's tissue distribution, subcellular localization, and interaction partners. In cancer studies, CREG1 antibodies have been employed to explore its dual role as a tumor suppressor or promoter, depending on context. Cardiovascular research utilizes these antibodies to study CREG1's involvement in vascular remodeling and cardiac repair. Validation of CREG1 antibodies includes testing for specificity via knockout controls or siRNA-mediated knockdown. Commercial availability from multiple suppliers has facilitated its adoption in studying lysosomal disorders, aging-related pathologies, and regenerative processes.