CRISP1抗体;CRISP1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13217(CRISP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13217(CRISP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

CRISP1 (Cysteine-Rich Secretory Protein 1) is a glycoprotein belonging to the CRISP family, characterized by conserved cysteine-rich domains involved in protein-protein interactions and extracellular signaling. Primarily expressed in the male reproductive tract (e.g., testes, epididymis), CRISP1 plays critical roles in sperm maturation, fertilization, and ion channel regulation. It facilitates sperm-egg fusion by interacting with egg surface receptors and modulates calcium and potassium channels during capacitation. Dysregulation of CRISP1 is linked to infertility and immune-mediated reproductive disorders.

CRISP1 antibodies are immunological tools targeting specific epitopes of the protein, widely used in reproductive biology and andrology research. These antibodies enable the detection of CRISP1 in tissues (via immunohistochemistry) or biological fluids (via ELISA/Western blot), aiding studies on sperm function, fertilization mechanisms, and autoimmune infertility. They also serve as biomarkers in diagnostic assays for male infertility and toxicology studies assessing reproductive toxicity.

Notably, CRISP1 antibodies may cross-react with homologous proteins (e.g., CRISP2/3) due to structural similarities, necessitating validation for specificity. Their applications extend to evolutionary studies, as CRISP proteins are conserved across vertebrates, and to venom research, as snake venom CRISPs share functional homology. Ongoing research explores their therapeutic potential in targeting reproductive pathologies or venom neutralization.