CUX1抗体;CUX1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13219(CUX1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13219(CUX1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The CUX1 antibody is a crucial tool in studying the CUT-like homeobox 1 (CUX1) protein, encoded by the CUX1 gene located on chromosome 7q22. CUX1 belongs to the Cut homeobox family of transcription factors, characterized by DNA-binding Cut domains and homeodomains. It regulates gene expression involved in cell proliferation, differentiation, and development, with roles in chromatin remodeling, cell cycle progression, and DNA repair. Aberrant CUX1 expression or mutations are linked to hematologic malignancies (e.g., AML, MDS) and solid tumors, where it may act as either an oncogene or tumor suppressor, depending on cellular context.

CUX1 antibodies are widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help identify CUX1 isoforms generated by alternative splicing or proteolytic processing, which exhibit distinct functional properties. In cancer research, these antibodies aid in exploring CUX1's dual role: full-length isoforms may promote tumorigenesis, while truncated forms are associated with genomic instability and poor prognosis. Additionally, CUX1 antibodies contribute to understanding developmental defects and autoimmune conditions linked to CUX1 dysregulation. Their specificity and validation remain critical for clarifying CUX1's complex biological mechanisms and therapeutic potential.