CLIP2抗体;CLIP2 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LOVO and NIH/3T3 cell lysates, Primary antibody: P13223(CLIP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13223(CLIP2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13223(CLIP2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CLIP2 (CAP-Gly domain-containing linker protein 2) antibody is a tool used to detect and study the CLIP2 protein, a cytoskeleton-associated protein involved in intracellular transport and microtubule dynamics. CLIP2 belongs to the cytoplasmic linker protein (CLIP) family, characterized by their CAP-Gly domains, which mediate interactions with microtubules and other proteins. It plays a role in linking endocytic vesicles to microtubules, facilitating organelle movement and maintaining cellular architecture.

CLIP2 has gained attention due to its association with pathological conditions. Studies suggest its dysregulation may contribute to cancers, such as papillary thyroid carcinoma and glioblastoma, where it influences cell proliferation and migration. Additionally, CLIP2 gene alterations are linked to neurological disorders, including a rare neurodevelopmental condition called "CLIP2-related intellectual disability."

The CLIP2 antibody is widely used in research applications, including Western blotting, immunofluorescence, and immunohistochemistry, to investigate protein expression, localization, and functional roles in disease models. Its development has enabled deeper insights into CLIP2's interplay with signaling pathways, such as EGFR and MAPK, which are critical for understanding tumor progression and neuronal function. Ongoing research aims to explore its potential as a diagnostic marker or therapeutic target in associated diseases.