H2BC1抗体;H2BC1 Antibody—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human prostate tissue, PC-3, A549 and TM4 cell lysates, Primary antibody: P13252(H2BC1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13252(H2BC1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13252(H2BC1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The H2BC1 antibody targets histone H2B type 1-C (H2BC1), a core component of nucleosomes involved in chromatin organization and epigenetic regulation. Histone H2B is one of the five major histone families (H1. H2A, H2B, H3. H4) that compact DNA into chromatin, playing critical roles in DNA packaging, transcription, replication, and repair. H2BC1. encoded by the *HIST1H2BC* gene, is a replication-dependent histone variant expressed during the S phase of the cell cycle. As part of the H2B family, it contributes to nucleosome stability and interacts with other histones to regulate chromatin accessibility.

H2BC1-specific antibodies are essential tools for studying histone modifications, chromatin dynamics, and gene expression patterns. They are widely used in techniques like chromatin immunoprecipitation (ChIP), immunofluorescence (IF), and Western blotting to investigate H2BC1's localization, post-translational modifications (e.g., phosphorylation, ubiquitination), and roles in cellular processes such as apoptosis or DNA damage response. Dysregulation of H2B variants, including H2BC1. has been implicated in cancer, developmental disorders, and epigenetic diseases, making these antibodies valuable for both basic research and clinical applications. Commercial H2BC1 antibodies are typically raised in rabbits or mice, with validation across multiple applications to ensure specificity and reproducibility.