FLNC抗体;FLNC Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 and NIH/3T3 cell lysates, Primary antibody: P13419(FLNC Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13419(FLNC Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13419(FLNC Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of FLNC Antibody**

Filamin C (FLNC), a member of the filamin protein family (FLNA, FLNB, FLNC), is a cytoskeletal actin-binding protein critical for maintaining structural integrity and mechanosensory functions in muscle tissues. FLNC is predominantly expressed in cardiac and skeletal muscles, where it stabilizes sarcomeres by crosslinking actin filaments and anchoring them to membrane complexes. It also interacts with signaling molecules, influencing cell adhesion, motility, and stress responses.

FLNC mutations are linked to myopathies (e.g., myofibrillar myopathy) and cardiomyopathies (e.g., hypertrophic or restrictive cardiomyopathy), often causing protein aggregation, sarcomere disruption, and impaired muscle function. FLNC antibodies are essential tools in research and diagnostics, enabling the detection of FLNC expression, localization, and pathological alterations via techniques like immunohistochemistry, Western blotting, and immunofluorescence.

Studies using FLNC antibodies have elucidated its role in disease mechanisms, including aberrant protein degradation and disrupted cytoskeletal signaling. Commercially available FLNC antibodies are validated for specificity, often targeting conserved regions (e.g., immunoglobulin-like domains). Their applications extend to evaluating tissue samples for FLNC-related pathologies and validating cellular models of FLNC dysfunction. Continued research aims to clarify FLNC's therapeutic potential in muscle disorders and its interplay with other sarcomeric proteins.