BICRA抗体;BICRA Antibody—艾普蒂 新品

The BICRA (BRD4-interacting chromatin remodeling complex-associated) protein, encoded by the BICRA gene, is a component of chromatin remodeling complexes that regulate gene expression by modifying chromatin structure. Initially identified as a binding partner of BRD4—a bromodomain protein involved in transcriptional elongation and epigenetic regulation—BICRA plays a role in mediating interactions between chromatin remodelers and transcriptional machinery. It is implicated in neural development, differentiation, and cellular homeostasis. Mutations in BICRA have been linked to Coffin-Siris syndrome (CSS), a rare genetic disorder characterized by developmental delays, intellectual disability, and distinct facial features. Additionally, BICRA alterations are observed in certain cancers, suggesting potential roles in oncogenesis. Antibodies targeting BICRA are essential tools for studying its expression, localization, and function in both normal and pathological contexts. They enable researchers to investigate BICRA's involvement in chromatin remodeling pathways, its interplay with BRD4. and its contribution to developmental disorders and cancer biology. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of BICRA's molecular mechanisms and therapeutic potential.