GOLGA3抗体;GOLGA3 Antibody—艾普蒂

The GOLGA3 antibody targets the GOLGA3 protein, also known as golgin A3 or GM130. a member of the golgin family localized to the Golgi apparatus. GOLGA3 plays a critical role in maintaining Golgi structure and function, including vesicle trafficking, protein glycosylation, and enzyme localization. Encoded by the *GOLGA3* gene on human chromosome 12. this 130 kDa protein is ubiquitously expressed and interacts with other Golgi matrix proteins (e.g., GRASP65) to stabilize stacked cisternae. Antibodies against GOLGA3 are widely used in research to study Golgi dynamics, fragmentation during mitosis, and disruptions in diseases like cancer or neurodegenerative disorders. They are essential tools for techniques such as immunofluorescence, Western blotting, and immunohistochemistry to visualize Golgi morphology or assess protein expression levels. Dysregulation of GOLGA3 has been linked to altered secretion pathways, tumor progression, and impaired cell polarity, making it a biomarker of interest in oncology and cell biology. Commercial GOLGA3 antibodies are typically raised in rabbits or mice, validated for specificity across human and model organisms. Researchers often employ these antibodies to explore Golgi-related mechanisms in cellular stress, membrane trafficking, and organelle biogenesis.