SNAPC5抗体;SNAPC5 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13492(SNAPC5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P13492(SNAPC5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SNAPC5 antibody targets the SNAPC5 (Small Nuclear RNA Activating Complex Polypeptide 5) protein, a key component of the SNAP complex (also known as the PTF complex). This evolutionarily conserved multiprotein complex is essential for the transcription initiation of small nuclear RNA (snRNA) genes by RNA polymerase III (Pol III). SNAPC5. along with other subunits (SNAPC1-4), binds to the proximal sequence element (PSE) in snRNA gene promoters, facilitating the recruitment of Pol III and coactivators. Structurally, SNAPC5 contains a conserved Myb DNA-binding domain critical for promoter recognition and complex stability.

Antibodies against SNAPC5 are widely used to study snRNA transcription regulation, investigate SNAP complex assembly, and explore its interactions with other transcriptional machinery. They are applied in techniques like chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to map SNAPC5 localization, expression levels, and its role in cellular processes such as splicing and ribosome biogenesis. Dysregulation of SNAPC5 has been implicated in developmental disorders and cancers, making these antibodies valuable tools for mechanistic and biomedical research. Validated SNAPC5 antibodies typically show specificity for human, mouse, or rat homologs, enabling cross-species studies.