HNRNPA3抗体;HNRNPA3 Antibody—艾普蒂

The HNRNPA3 antibody targets the heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), a member of the hnRNP family involved in RNA metabolism, including splicing, transport, and stability. HNRNPA3 contains RNA-binding domains (RRMs) and a prion-like domain, which facilitates liquid-liquid phase separation and stress granule formation. Mutations in its prion-like domain are linked to protein aggregation in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). HNRNPA3 also plays roles in telomere maintenance and mRNA export. Antibodies against HNRNPA3 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate its involvement in cancer (e.g., hepatocellular carcinoma) and neurodegeneration. Validated antibodies help identify disease-associated mislocalization or aggregation of HNRNPA3. providing insights into mechanisms of RNA dysregulation and potential therapeutic targets. Researchers often verify specificity using knockout controls or siRNA knockdown to ensure accurate detection across species, particularly human and mouse models.