CAMSAP3抗体;CAMSAP3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P13707(CAMSAP3 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

CAMSAP3 (Calmodulin-Regulated Spectrin-Associated Protein 3) is a member of the CAMSAP/Patronin family involved in organizing microtubule networks by stabilizing their minus ends. It plays critical roles in establishing cell polarity, maintaining cytoskeletal architecture, and regulating intracellular transport. CAMSAP3 antibodies are immunological tools designed to detect and study this protein in various experimental settings, such as immunofluorescence, Western blotting, or immunoprecipitation. These antibodies are typically generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments corresponding to conserved regions of human CAMSAP3.

Research using CAMSAP3 antibodies has revealed its localization to microtubule-organizing centers and its involvement in epithelial cell polarization, mitotic spindle orientation, and neuronal development. Dysregulation of CAMSAP3 is linked to pathologies, including cancer metastasis and neurodevelopmental disorders. Validated CAMSAP3 antibodies help distinguish its unique isoforms and post-translational modifications, aiding mechanistic studies. Commercial antibodies often undergo specificity verification via knockout cell lines or siRNA knockdown. As CAMSAP3 interacts with key regulators like KIF3A and LL5β, its antibodies are valuable for exploring microtubule dynamics in cellular models (e.g., HeLa, MDCK) and disease contexts. Proper validation remains essential due to potential cross-reactivity with other CAMSAP family members.