TP53I3抗体;TP53I3 Antibody—艾普蒂 新品

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     Western blot analysis using TP53I3 mouse mAb against  HT-29 lysate    

  
  

The TP53I3 (Tumor Protein 53 Inducible Protein 3) antibody is a research tool designed to detect and study the TP53I3 protein, a p53-regulated gene product implicated in cellular stress responses. TP53I3. also known as PIG3. is encoded by a gene transcriptionally activated by the tumor suppressor p53 in response to DNA damage or oxidative stress. It functions as a quinone oxidoreductase, participating in redox regulation and apoptosis, and may contribute to p53-mediated tumor suppression by promoting reactive oxygen species (ROS) accumulation or modulating metabolic pathways.

Antibodies targeting TP53I3 are commonly used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate its expression, localization, and regulation in various biological contexts. These antibodies help researchers explore TP53I3's role in cancer, aging, and oxidative stress-associated diseases. Validation often includes specificity checks via knockout cell lines or siRNA-mediated knockdown. Studies using TP53I3 antibodies have revealed its variable expression across cancer types, with potential links to chemoresistance or tumor progression. However, its precise mechanisms remain under investigation, and antibody reliability depends on rigorous validation due to possible cross-reactivity with homologous proteins. Such tools are critical for dissecting TP53I3's functional interplay within p53 signaling networks and its therapeutic relevance.