CCDC140抗体;CCDC140 Antibody—艾普蒂 新品

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     IHC-P analysis of stomach tissue by CCDC140 antibody (P16020) IHC-P was performed using sections of the formalin-fixed paraffin-embedded stomach tissue;Result: Glandular cells are positively stained at the cytoplasm.    

  
  

The CCDC140 antibody targets the Coiled-Coil Domain Containing 140 (CCDC140) protein, a less-characterized member of the CCDC family implicated in cellular processes such as cytoskeletal organization, intracellular trafficking, and cell cycle regulation. CCDC proteins typically feature coiled-coil domains that mediate protein-protein interactions, suggesting CCDC140 may function as a structural or regulatory scaffold. While its exact biological role remains unclear, CCDC140 has been tentatively linked to centrosome dynamics and mitotic spindle assembly, based on homology with related CCDC proteins.

Antibodies against CCDC140 are primarily utilized in basic research to investigate its expression patterns, subcellular localization, and interactions. Studies have detected CCDC140 in diverse tissues, with variable expression levels reported in cancers, hinting at potential diagnostic or prognostic relevance. Commercial CCDC140 antibodies are typically polyclonal or monoclonal raised in rabbits or mice, validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. However, specificity challenges persist due to limited characterization data and shared epitopes among CCDC family members. Recent efforts focus on optimizing antibody validation using knockout cell lines to confirm target specificity. As CCDC140 gains attention in cellular mechanobiology and oncology, its antibodies serve as critical tools to elucidate its role in health and disease.