SEC62抗体;SEC62 Antibody—艾普蒂

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

SEC62 (also known as translocation protein SEC62) is a key component of the endoplasmic reticulum (ER) membrane, playing a critical role in protein translocation and post-translational transport. It forms part of the SEC61 translocon complex, which facilitates the co-translational insertion of nascent polypeptides into the ER and supports the retrograde transport of misfolded proteins for ER-associated degradation (ERAD). SEC62 is particularly vital in maintaining ER homeostasis and cellular stress responses.

SEC62 antibodies are immunological tools used to detect and study this protein in various research contexts. These antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes of human SEC62. They enable applications such as Western blotting, immunofluorescence, and immunohistochemistry to investigate SEC62 expression, localization, and interactions in cell lines or tissue samples. Dysregulation of SEC62 has been implicated in cancers, including prostate, lung, and thyroid cancers, where its overexpression is linked to tumor progression, metastasis, and therapy resistance. SEC62 antibodies thus serve as valuable reagents in cancer research, helping to explore its role as a potential biomarker or therapeutic target. Commercial SEC62 antibodies are often validated for specificity using knockout cell lines or siRNA-mediated silencing. Researchers rely on these antibodies to advance understanding of ER biology, protein quality control mechanisms, and cancer pathophysiology.