LaminBReceptor抗体;LaminBReceptor Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Lamin B Receptor expression in Jurkat cell lysate.    

  
  

The Lamin B Receptor (LBR) is an integral nuclear membrane protein primarily localized to the inner nuclear membrane. It plays critical roles in nuclear envelope assembly, chromatin organization, and tethering heterochromatin to the nuclear periphery. Structurally, LBR contains an N-terminal nucleoplasmic domain that interacts with chromatin and chromatin-binding proteins (e.g., HP1), and a C-terminal hydrophobic domain with sterol reductase activity. Mutations in the LBR gene are linked to human disorders like Pelger-Huët anomaly (a blood cell morphology defect) and Greenberg skeletal dysplasia.

Antibodies targeting LBR are essential tools for studying nuclear envelope dynamics, chromatin architecture, and disease mechanisms. They are widely used in techniques such as immunofluorescence, Western blotting, and immunohistochemistry to visualize LBR localization, expression levels, and interactions. In research, these antibodies help investigate LBR's roles in mitosis (e.g., nuclear envelope reformation), its involvement in cellular senescence (nuclear morphology changes), and its dysregulation in cancers or laminopathies. Commercial LBR antibodies are typically raised against specific epitopes, such as the N-terminal region, and require validation for species cross-reactivity and application-specific performance. Recent studies also explore LBR's potential as a biomarker in age-related diseases or its crosstalk with signaling pathways, underscoring its multifaceted biological significance.