MINA53抗体;MINA53 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of MINA53 expression in A431 cell lysate.    

  
  

MINA53 antibody targets the MINA53 protein, a member of the JmjC domain-containing family implicated in ribosomal RNA (rRNA) processing and epigenetic regulation. MINA53. also known as MINA53 or NO52. is a 53 kDa protein encoded by the *MINA* gene in humans. It functions as a ribosomal oxygenase, utilizing iron and α-ketoglutarate to catalyze histone demethylation and hydroxylation of specific ribosomal proteins, thereby influencing ribosome biogenesis and translation efficiency. MINA53 is involved in cell proliferation, differentiation, and oncogenesis, with overexpression observed in cancers like hepatocellular carcinoma and colorectal cancer, correlating with poor prognosis.

Antibodies against MINA53 are essential tools for studying its expression, localization, and function. They are commonly used in techniques such as Western blotting, immunofluorescence (IF), and immunohistochemistry (IHC) to detect MINA53 in cell lines, tissues, or tumor samples. These antibodies aid in elucidating MINA53's role in linking metabolic pathways to epigenetic and translational regulation, particularly under hypoxic conditions or during oncogenic stress. Validated MINA53 antibodies typically recognize specific epitopes within its conserved JmjC or C-terminal domains, ensuring specificity. Researchers rely on these reagents to explore MINA53's potential as a therapeutic target or biomarker in cancer and other diseases linked to ribosomal dysfunction.