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ERp57抗体;ERp57 Antibody—艾普蒂新品

Rabbit Monoclonal ERp57 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-29

上海切尔齐生物科技有限公司

非会员

联系人：周***

电话：027***

手机：180***

邮箱：nuo***

产品详情:

中文名称：: ERp57抗体

英文名称：: Rabbit Monoclonal ERp57 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 8079 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: ERp57

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	1/20-1/50	Human,Mouse,Rat
IHC	1/100-1/200	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	ERp57; ERp60; ERp61; Glucose Regulated Protein 58 Kd; HsT17083; p58; PDIA3; Phospholipase C alpha; PI PLC;;ERp57
WB Predicted band size	57 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human ERp57
Formulation	Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
Western blot analysis of ERp57 expression in HepG2 cell lysate.

参考文献

以下是关于ERp57抗体的3篇参考文献示例(文献信息为示例性质，请通过学术数据库核实)：

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1. **文献名称**: "ERp57: A multifunctional protein in the endoplasmic reticulum"

**作者**: Ellgaard L, Frickel EM

**摘要**: 综述ERp57作为硫氧还蛋白家族成员在内质网中的作用，包括参与MHC I类分子组装、蛋白质二硫键异构化及与钙网蛋白/钙联蛋白复合物的相互作用机制。

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2. **文献名称**: "ERp57 expression in cancer cells and its role in chemoresistance"

**作者**: Coe H, Jung J, Lee S

**摘要**: 研究ERp57在多种癌细胞系中的高表达现象，揭示其通过调控未折叠蛋白反应(UPR)促进肿瘤细胞存活及化疗耐药性的分子通路。

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3. **文献名称**: "ERp57 interacts with SARS-CoV-2 spike protein and modulates viral entry"

**作者**: Zhang Y, et al.

**摘要**: 探讨ERp57与新冠病毒刺突蛋白的相互作用，发现其通过影响病毒受体结合域(RBD)的构象变化，可能参与调控病毒入侵宿主细胞的效率。

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如需具体文献，建议通过PubMed或Google Scholar以关键词“ERp57 antibody”、“PDIA3 function”或“GRP58”检索最新研究。

背景信息

ERp57 (Endoplasmic Reticulum Protein 57), also known as PDIA3 or GRP58. is a member of the protein disulfide isomerase (PDI) family. It localizes primarily within the endoplasmic reticulum (ER) and plays a critical role in protein quality control by catalyzing disulfide bond formation, isomerization, and assisting in the folding of nascent glycoproteins. ERp57 interacts with lectin chaperones calnexin and calreticulin, forming a complex that ensures proper folding of MHC class I molecules and other glycoproteins. Beyond its canonical role, ERp57 has been implicated in diverse cellular processes, including calcium homeostasis, cell adhesion, and immune response regulation.

Dysregulation of ERp57 is linked to various diseases. Overexpression is observed in cancers, correlating with tumor progression, drug resistance, and poor prognosis. Conversely, reduced ERp57 activity is associated with neurodegenerative disorders like Alzheimer’s disease, possibly due to impaired protein folding. ERp57 also participates in viral infection mechanisms, aiding in the processing of viral glycoproteins.

ERp57 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate ERp57’s role in physiological and pathological contexts. Specific antibodies help identify its interaction partners and post-translational modifications, contributing to therapeutic research targeting ERp57-related pathways. However, antibody specificity must be validated due to structural similarities among PDI family members.

ERp57抗体;ERp57;ERp57 Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学