IP3Receptor抗体;IP3Receptor Antibody—艾普蒂 新品

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Flow cytometric analysis of MCF-7 cells using CEBPB mouse mAb (blue) and negative control (red).    

  
  

The IP3 receptor (IP3R) antibody is a crucial tool in studying the inositol 1.4.5-trisphosphate receptor, a calcium-permeable channel located in the endoplasmic reticulum membrane. IP3Rs mediate intracellular calcium release, a process central to cellular signaling pathways regulating processes like apoptosis, metabolism, gene expression, and neurotransmitter release. Three isoforms (IP3R1. IP3R2. IP3R3) exist, with tissue-specific expression patterns and functional differences. Antibodies targeting IP3Rs are widely used in research to investigate receptor localization, expression levels, and regulatory mechanisms in physiological or pathological contexts.

These antibodies are essential for techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. Their specificity is critical, as cross-reactivity between isoforms can complicate data interpretation. Dysregulation of IP3R signaling is implicated in neurodegenerative diseases, cancer, cardiac arrhythmias, and immune disorders. For example, altered IP3R1 expression is linked to Huntington’s disease, while IP3R3 overexpression is observed in certain cancers.

Commercial IP3R antibodies are typically raised against isoform-specific epitopes, though validation remains challenging due to structural similarities. Recent advances include phospho-specific antibodies to study post-translational modifications regulating IP3R activity. Despite challenges, these antibodies remain indispensable for unraveling calcium signaling complexities and developing therapeutic strategies targeting IP3R-associated pathologies.