Carbonicanhydrase2抗体;Carbonicanhydrase2 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Carbonic anhydrase 2 expression in A431 cell lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

Carbonic anhydrase 2 (CA-II) is a zinc-metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons, playing a critical role in pH regulation, ion transport, and fluid balance. It is widely expressed in tissues, including kidneys, erythrocytes, gastric mucosa, and the central nervous system. CA-II dysfunction is linked to genetic disorders like osteopetrosis with renal tubular acidosis and cerebral calcification, as well as acquired conditions such as glaucoma and cancer.

Antibodies targeting CA-II are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CA-II's role in diseases. For example, in cancer research, CA-II antibodies help explore tumor microenvironment acidification, a process linked to metastasis and drug resistance. In neurology, they aid in examining CA-II's involvement in pH homeostasis and neurodegenerative disorders.

CA-II antibodies are typically validated for specificity across species, particularly human and mouse, ensuring reliability in diverse experimental models. Their applications extend to diagnostic assays, therapeutic target validation, and biomarker discovery, underscoring their importance in both basic research and clinical translation.