Dyneinintermediatechain1抗体;Dyneinintermediatechain1 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Dynein intermediate chain 1 expression in mouse testis lysate.    

  
  

Dynein intermediate chain 1 (IC1) antibody is a specialized tool used to study the cytoplasmic dynein 1 complex, a critical motor protein responsible for retrograde intracellular transport along microtubules. Cytoplasmic dynein plays essential roles in mitotic spindle organization, organelle positioning, vesicle trafficking, and neuronal function. The intermediate chain (IC) subunits, including IC1 (encoded by DYNC1I1 in humans), serve as structural and regulatory components that link the dynein heavy chain to other adaptor proteins (e.g., dynactin) and cargoes. IC1 is involved in binding regulatory factors and modulating dynein’s ATPase activity, ensuring precise spatiotemporal control of transport processes.

Antibodies targeting IC1 enable researchers to investigate dynein complex assembly, localization, and function in diverse biological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression levels, subcellular distribution, and interaction partners. Dysregulation of dynein-mediated transport is implicated in neurodegenerative diseases (e.g., ALS, Huntington’s), ciliopathies, and cancer metastasis, making IC1 antibodies valuable for mechanistic studies in these areas.

These antibodies are often validated for specificity using knockout controls or siRNA knockdown to confirm signal loss. Researchers should verify species reactivity (e.g., human, mouse, rat) and compatibility with intended applications, as IC1 exists in multiple splice variants and may undergo post-translational modifications affecting antibody recognition.