IKBepsilon抗体;IKBepsilon Antibody—艾普蒂 新品

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     Western blot analysis of IKB epsilon expression in HeLa cell lysate.    

  
  

IKBepsilon (also known as NFKBIA or IKBA) is a member of the IκB (inhibitor of kappa B) protein family, which regulates the activity of NF-κB transcription factors. These transcription factors play pivotal roles in immune responses, inflammation, cell survival, and proliferation. Under resting conditions, IκBepsilon binds to NF-κB dimers (e.g., p50/p65) in the cytoplasm, masking their nuclear localization signals and preventing transcriptional activation. Upon cellular stimulation (e.g., cytokines, pathogens, or stress), IκBepsilon undergoes phosphorylation by the IκB kinase (IKK) complex, leading to its ubiquitination and proteasomal degradation. This releases NF-κB, allowing its nuclear translocation and target gene expression.

Compared to other IκB proteins like IκBα or IκBβ, IκBepsilon exhibits distinct tissue-specific expression patterns, with higher abundance in immune cells, and displays unique kinetic properties in NF-κB regulation. Its expression is dynamically modulated during immune activation, suggesting a role in fine-tuning NF-κB responses. Antibodies targeting IκBepsilon are essential tools for studying its expression, post-translational modifications, and interactions in signaling pathways. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore its involvement in inflammatory diseases, autoimmune disorders, and cancer. Research on IκBepsilon also contributes to understanding feedback mechanisms that restore cellular homeostasis after NF-κB activation.