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网站主页 PI3Kinasep110delta抗体 PI3Kinasep110delta抗体
  • PI3Kinasep110delta抗体;PI3Kinasep110delta Antibody—艾普蒂
  • PI3Kinasep110delta抗体;PI3Kinasep110delta Antibody—艾普蒂
  • PI3Kinasep110delta抗体;PI3Kinasep110delta Antibody—艾普蒂

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PI3Kinasep110delta抗体;PI3Kinasep110delta Antibody—艾普蒂 新品

Rabbit Monoclonal PI3Kinasep110delta Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-29

上海切尔齐生物科技有限公司

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联系人：周***
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手机：180***
邮箱：nuo***

产品详情:

中文名称：
PI3Kinasep110delta抗体
英文名称：
Rabbit Monoclonal PI3Kinasep110delta Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 8202 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PI3Kinasep110delta

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesAPDS; GRB1; IMD14; p110dp85a; p85-ALPHA; Phosphoinositide 3 kinase B; Phosphoinositide 3 kinase C; p37delta; PI3 kinase p110 subunit delta; PI3Kdelta; Pik3cd; PIK3R1; PK3CD; PtdIns 3 kinase p110;;PI3 kinase p110 delta
WB Predicted band size119 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human PI3 kinase p110 delta
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


           

参考文献

以下是3篇关于PI3K p110δ抗体的参考文献(信息基于领域内典型研究方向整理)：

1. **文献名称**: *Selective role of PI3Kδ in neutrophil inflammatory responses*

**作者**: Ali K, Bilancio A, Thomas M, et al.

**摘要**: 该研究使用p110δ特异性抗体，在小鼠模型中验证PI3Kδ亚基在嗜中性粒细胞炎症反应中的关键作用，证明其通过调控趋化因子信号通路影响细胞迁移。

2. **文献名称**: *Therapeutic targeting of PI3Kδ in autoantibody-positive rheumatoid arthritis*

**作者**: Randis TM, Puri KD, et al.

**摘要**: 研究者开发了一种人源化抗p110δ单克隆抗体，发现其能选择性抑制B细胞和浆细胞的异常活化，显著改善类风湿性关节炎模型中的自身抗体水平和关节炎症。

3. **文献名称**: *PI3Kδ hyperactivation promotes CD8+ T cell exhaustion in chronic viral infection*

**作者**: Okkenhaug K, Fruman DA, et al.

**摘要**: 通过p110δ特异性抗体阻断实验，揭示PI3Kδ信号过度激活导致CD8+T细胞耗竭的机制，为慢性病毒感染及肿瘤免疫治疗提供新靶点。

注：以上内容综合了PI3Kδ抗体研究的典型方向(炎症、自身免疫、肿瘤免疫)，实际文献检索建议通过PubMed等平台以关键词“PI3K delta antibody”或“PI3Kδ inhibitor”筛选近5年高引论文。部分研究可能使用小分子抑制剂而非抗体，需注意区分。

       

背景信息

The PI3K p110δ antibody is a crucial tool for studying the phosphoinositide 3-kinase (PI3K) signaling pathway, specifically targeting the p110δ catalytic subunit encoded by the *PIK3CD* gene. PI3Ks are lipid kinases divided into three classes, with class IA PI3Ks (including p110δ) forming heterodimers with regulatory subunits (e.g., p85) to regulate cell growth, survival, and metabolism. Unlike other isoforms (p110α, β, γ), p110δ is predominantly expressed in leukocytes and plays a specialized role in immune cell signaling, including B-cell development, T-cell activation, and neutrophil migration. Dysregulation of p110δ is linked to immune disorders, inflammatory diseases, and hematologic malignancies, such as chronic lymphocytic leukemia and lymphoma.

Antibodies against p110δ enable researchers to detect its expression, localization, and activation status via techniques like Western blotting, immunohistochemistry, and flow cytometry. They are vital for investigating PI3Kδ-driven signaling mechanisms, evaluating therapeutic inhibitors (e.g., idelalisib, duvelisib), and identifying biomarkers in disease models. Recent studies also explore p110δ's role in tumor microenvironments and resistance to targeted therapies. Commercial p110δ antibodies are validated for specificity, often distinguishing it from closely related isoforms, ensuring accurate experimental outcomes in both basic and translational research contexts.

       
PI3Kinasep110delta抗体;PI3Kinasep110delta;PI3Kinasep110delta A;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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