CDT2抗体;CDT2 Antibody—艾普蒂

The CDT2 antibody targets the protein CDT2 (also known as DCAF2 or L2DTL), a key substrate receptor for the CRL4 (Cullin4-RING E3 ubiquitin ligase) complex. CDT2 plays a critical role in cell cycle regulation, particularly during DNA replication and damage response. It facilitates the ubiquitination and proteasomal degradation of replication licensing factors like CDT1. CDC6. and the histone methyltransferase SET8. ensuring precise control of DNA replication to prevent re-replication and maintain genomic stability. CDT2 is also involved in the replication stress response by regulating the degradation of these substrates in a PCNA (proliferating cell nuclear antigen)-dependent manner. Dysregulation of CDT2 has been linked to genomic instability, cancer progression, and developmental disorders. Overexpression of CDT2 is observed in various cancers, correlating with poor prognosis. Antibodies against CDT2 are essential tools for studying its expression, localization, and interaction partners in cellular processes. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to explore its role in DNA replication fidelity, cell cycle checkpoints, and tumorigenesis. Research on CDT2 continues to shed light on its therapeutic potential in cancer and diseases linked to DNA repair defects.