PTPRR抗体;PTPRR Antibody—艾普蒂

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     Western blot analysis of PTPRR expression in mouse brain lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

The PTPRR (Protein Tyrosine Phosphatase Receptor Type R) antibody is a research tool used to detect and study the PTPRR protein, a member of the protein tyrosine phosphatase (PTP) family. PTPRR, also known as PTP-SL or PTPBR7. is a receptor-type phosphatase implicated in regulating mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating ERK1/2. It plays a role in neuronal development, synaptic plasticity, and cellular processes like proliferation and differentiation. The antibody is essential for investigating PTPRR's expression, localization, and function in various tissues, particularly the brain, where it is highly expressed.

Researchers utilize PTPRR antibodies in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore its involvement in diseases like neurodegenerative disorders, cancer, and autoimmune conditions. Studies suggest PTPRR may act as a tumor suppressor or oncogene depending on context, with altered expression observed in gliomas, colorectal cancer, and other malignancies. Its role in modulating immune responses and neural signaling also makes it relevant in neuroinflammation and psychiatric disorders.

Antibodies targeting PTPRR are typically raised against specific epitopes, requiring validation for specificity to avoid cross-reactivity with other PTPs. Commercial availability of monoclonal or polyclonal variants supports diverse experimental needs. Ongoing research aims to clarify its mechanistic contributions to disease pathways and potential therapeutic applications.