ACAP2抗体;ACAP2 Antibody—艾普蒂

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     Western blot analysis of ACAP2 expression in 293 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

ACAP2 (ArfGAP with Coiled-Coil, ANK Repeat, and PH Domain-containing Protein 2) is a member of the ArfGAP protein family, which regulates ADP-ribosylation factor (Arf) GTPases involved in membrane trafficking, cytoskeletal organization, and cell migration. It acts as a GTPase-activating protein (GAP) to promote the hydrolysis of GTP-bound Arf to its inactive GDP-bound form, modulating vesicle formation and cargo sorting. ACAP2 contains distinct functional domains, including a coiled-coil motif, ankyrin repeats, and a pleckstrin homology (PH) domain, enabling interactions with lipids, proteins, and cellular membranes.

ACAP2-specific antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ACAP2's role in processes such as receptor endocytosis, neuronal development, and cancer metastasis. Research links ACAP2 to pathologies, including glioblastoma invasiveness and metabolic disorders, highlighting its potential as a therapeutic target. Validated antibodies help clarify its regulatory mechanisms, such as phosphorylation-dependent signaling crosstalk or membrane dynamics in cellular protrusions. Commercial antibodies often target epitopes within its N-terminal or PH domains, with specificity confirmed via knockout controls.