EMC4抗体;EMC4 Antibody—艾普蒂 新品

The EMC4 antibody targets the EMC4 subunit of the endoplasmic reticulum membrane protein complex (EMC), a conserved multi-protein assembly critical for membrane protein biogenesis. First identified in yeast, the EMC (with 6-10 subunits across species) facilitates the insertion, folding, and stabilization of transmembrane domain (TMD)-containing proteins, particularly those with complex topologies. EMC4. also known as TMEM85. is an integral membrane protein that contributes to the complex's structural integrity and function. Studies link EMC to lipid transfer, ion channel regulation, and the maturation of G protein-coupled receptors (GPCRs) or neurotransmitter transporters. Dysregulation of EMC subunits, including EMC4. has been implicated in neurodevelopmental disorders, cancer, and diseases linked to defective protein quality control. Antibodies against EMC4 are widely used in research to study EMC complex localization, expression levels, and interactions via techniques like Western blotting, immunofluorescence, or co-immunoprecipitation. Their specificity aids in elucidating EMC4's role in cellular homeostasis and disease mechanisms. Commercial EMC4 antibodies are typically raised in rabbits or mice, validated for cross-reactivity in human, mouse, or rat models, and serve as essential tools for probing EMC-related pathways.