UCHL5IP抗体;UCHL5IP Antibody—艾普蒂 新品

The UCHL5IP antibody is designed to detect UCHL5IP (Ubiquitin C-terminal Hydrolase L5-Interacting Protein), a protein also known as WDR48 or SPG48. UCHL5IP belongs to the WD40 repeat protein family and functions as a regulatory cofactor for deubiquitinating enzymes (DUBs), particularly UCHL5 (UCH37), within the ubiquitin-proteasome system. This protein plays a critical role in modulating protein degradation by assisting UCHL5 in hydrolyzing ubiquitin chains, thereby influencing substrate specificity and activity. UCHL5IP is involved in diverse cellular processes, including DNA repair, transcriptional regulation, spindle assembly during mitosis, and stress response. Dysregulation of UCHL5IP has been implicated in diseases such as cancer, neurodegenerative disorders, and hereditary spastic paraplegia (SPG48 subtype). The UCHL5IP antibody is widely used in research to investigate the protein’s expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Studying UCHL5IP provides insights into ubiquitin-dependent pathways, cellular homeostasis, and disease mechanisms, offering potential therapeutic targets for conditions linked to proteasomal dysfunction.