CSDE1抗体;CSDE1 Antibody—艾普蒂

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     Western blot analysis of CSDE1 expression in (1) 293 cell lysate; (2) Mouse brain lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:1K dilution)    

  
  

The CSDE1 (Cold Shock Domain Containing E1) protein, also known as UNR (Upstream of N-Ras), is an RNA-binding protein involved in post-transcriptional regulation of gene expression, including translation, stability, and localization of target mRNAs. It plays critical roles in cellular processes such as proliferation, differentiation, and stress responses. Dysregulation of CSDE1 has been linked to cancer progression, neurodegenerative diseases, and viral infections, highlighting its importance in both physiological and pathological contexts.

CSDE1 antibodies are essential tools for studying its expression, localization, and molecular interactions. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and RNA immunoprecipitation (RIP) to investigate CSDE1's regulatory mechanisms. For example, studies have shown that CSDE1 promotes tumor growth in cancers like melanoma and colorectal cancer by enhancing the translation of oncogenic mRNAs. Antibodies targeting CSDE1 help validate its overexpression in clinical samples, providing insights into its potential as a diagnostic or prognostic biomarker.

Additionally, CSDE1 antibodies aid in exploring its role in neuronal development and stress granule formation, relevant to neurodegenerative conditions such as Alzheimer’s disease. Commercial CSDE1 antibodies are typically raised in rabbits or mice, with validation across multiple applications to ensure specificity. Ongoing research continues to uncover CSDE1's multifaceted roles, driving demand for reliable antibodies to support mechanistic and therapeutic studies.